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Both excesses and deficiencies of certain nutrients, as well as exposure to heavy metals, toxins, and endocrine disruptors, can disrupt immune tolerance

Additionally, because BPC-157 products are unregulated, contamination with other substances represents a significant concern, and some studies suggest that between 12% and 58% of ergo-nutritional supplements may be contaminated with other substances

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Aging reduces NAD+ synthesis pathways while increasing consumption by enzymes like CD38 and PARPs, activated by inflammation and damage.[13][15] CD38, an immune-related enzyme, ramps up with age, breaking down NAD+ precursors